So, in a few comments or somewhere, I may have mentioned something I thought would be interesting, and I imagine some of my Trek-loving readers can probably help fill in details: The Next Gen crew is my favorite Star Trek crew, but DS9 is my favorite setting. So, what'd happen if you mixed the two together? Replace the Star Fleet portion of DS9's cast with the Next Gen crew: Kira, Quark, Garak, and so forth are still there, but have to mesh with different people. Some thoughts of mine:
Originally, the writers intended for Ro Laran to be on DS9, but because Michelle Forbes wasn't interested, they made Kira. It might be an interesting can of worms to contemplate.
Picard would have an interesting time if he ended up the Emissary, not wanting to violate the Prime Directive. He's already been briefly worshiped as a god, and I don't think he'd enjoy being Space Jesus.
Not sure how Data would fit in: He'd probably do well in Dax's job as a science officer, since his 88 petabytes of memory would give him something comparable to Dax's multiple lifetimes' experience. Of course, Data would be in a very different character role. I suppose he might find some kind of kinship with Odo, since they're both outsiders among organic humanoids.
Deanna's kind of hard to work with because, well, you probably know why. Guess she could do something with Keiko's school and/or serve in a diplomatic capacity.
Wesley'd probably fill out the role of Jake Sisko, only in a more annoying manner. Have a hard time imagining him forming a friendship with Nog, though.
Might need to give thought to Geordi versus Miles for the role of chief engineer. The chief was already in the show, but was also on the Enterprise.
So anyway, begin discussion.