Skeptico recently posted an excellent article I will probably link to plenty of times in the future. In fact I should probably add a link as a "see also" in the Doggerel Index. It gave me a bit of a flashback to an idiot troll calling himself "Mr. FreeThinker" who apparently thought "we don't know yet" counts as an extraordinary claim. This is, of course, to borrow a phrase from across the pond, utter bollocks.
I also had a flashback to a clip of Bill O'Reilly with Richard Dawkins. He essentially said that as long as us scientifically minded people don't know, he's free to believe whatever random stuff some guys just made up ex nihilo. That, of course, makes it a matter of pure, baseless faith.
Of course, science has given us great knowledge. We know evolution happened and have a damn good idea about many of the details. We know the Earth revolves around the sun. We know The Big Bang happened. The evidence for all of these things gives us >99% confidence. Of course, we can't know everything, since we can't shove the entire universe into an evidence locker or examine the whole of its lifespan. There are still unanswered questions, like what happened before the Big Bang, or even if that's a meaningful question.
Yes, we've got a lot of cosmologists doing mathematical calculations of what happens when you play Cat's Cradle with superstrings, trying to figure out those answers. Who knows, they might find and successfully test an answer. Right now, they don't, and many of my fellow skeptics have expressed doubts about the whole approach since testability is hard to come by. In any case, we don't know yet. Not knowing is only a mild irritation for most of us, and often exciting for those doing the research: They're going to get a surprise, no matter what the results are.
For faithheads, not knowing is somehow an indictment for science: Because science isn't perfect, they need to make up a perfect being to tell them what to believe. Of course, there are a lot of these fictional beings competing for dominance because evidence isn't involved. Seems to me you could pick one or a set at random and still be on equal ground with all the other stone idol roulette players.
Of course, I think the only winning move is not to play.